mRNA vaccine technology

As soon as the severity of the lockdown, quarantine and asocial distancing corona-measures were deployed, a lot of pharmaceutical industries as well as research groups of all kind (private and governmental) started to investigate the development of a vaccine in which the hope was sold to be able to return to our normal lives.

It was to be expected from the very beginning that there would be lobbying for certain vaccines by certain shareholder groups. Indeed, the fact that the covid-19 vaccines from Pfizer-BioNTech and Moderna were the first to be approved speaks for itself. Both pharmaceutical concerns are mainly controlled by the same share holderssuch as the Vanguard group, Blackrock Inc., State Street Corporation and Geode Capital Management.

Moreover, the vaccines from both Pfizer and Moderna are based on completely new mRNA technology. Classic vaccines do contain parts of the virus protein capsid to which the body raises antibodies that should recognize the virus when it enters the body.

The mRNA vaccines have another mode of action: a part of the genetic code of the virus -that encodes for certain of those capsid proteins- is injected. The mRNA enters in the cell and the latter will use this mRNA template to assemble these viral capsid proteins, to which also antibodies can be generated.

The possibility mRNA vaccine technology2 is not new as such, it has been studied since the early nineties, but it has always been pushed back by all kind of regulatory commissions because of the safety concerns, especially on the long term.

What if the mRNA integrates in the cell and persists there, forcing the cell to create viral proteins for the rest of your live? Can it lead to new diseases? How will the immune system be affected by this technology on the long term? Can it lead to a new kind of auto-immune diseases3?

These long-term effects are UNKNOWN YET which makes this vaccination program one of the biggest experiments in the pharmaceutical history. If the blunting corona measures already killed half of your brain, please feel free to volunteer in this gigantic clinical trial by betting the remainder of your brain hemisphere.

The corona-crisis can at least be regarded as an insurmountable opportunity to have the mRNA technology forced through all kind of boards and committees to get emergency approval for human use, the “urge” for whatever vaccine was high enough to pass the green light.

The mRNA vaccines are “Conditional marketing authorization granted4 which basically means a quick authorization to accelerate the approval with respect to the necessity for human healthcare.

Necessity knows no law, except the “follow the money”-law. The economic model behind those mRNA vaccines is quite interesting; not for you as an individual, but for the shareholders of the vaccination industry of course. Even the fact that the storage costs of this type of vaccines is much higher (since RNA molecules are quite unstable and must therefore be stored at -80°C), the general profit is huge compared to classic vaccines.

Besides RNA stabilizing agents (like PEG5 which are also a source of concern), the mRNA vaccine does contain not much more than a part of the RNA of the coronavirus. More specifically the part that is needed to build the capsid protein that binds to certain cell surface molecules in your body. Thereby the virus wall components need to be assembled using recombinant DNA techniques in cell cultures and purified therefrom.

Using a part of the mRNA directly extracted from whatever virus and amplified (also by PCR techniques), one can bypass a couple of expensive steps in the vaccination production process.

For the time being, the vaccine manufacturers claim their product is still effective against virus mutations that popped up by the end of 2020, such as the so-called British and South-African mutations.

When the virus mutates beyond the point that the current vaccines are no longer working effectively, (and they will!), mRNA vaccine manufacturers already claimed they could generate an adapted vaccine in only 6 weeks, if necessary. The amazing advantage of mRNA vaccines lies in the fact that when a mutated corona-strain pops up, it’s way much faster and easier and -most important- much cheaper to manufacture a new adapted vaccine towards the new strain; thus, enabling much more profit for the vaccination industry.

Finally, this is exactly what the vaccination industry wants: to produce each year a new type of vaccine adapted to the seasonal corona virus of that time, and this with a minimum of costs! Extreme huge profits can be made each year again! And now these vaccines are relatively cheap, but they will increase in price year after year. And people will be willing to pay for it either out of fear or because it will be necessary to regain some of our freedom (such as traveling).

To give you an idea about the profit margin: the cheaply produced mRNA vaccines do cost about 4 to 5 times less than the AstraZeneca vaccine which is produced using the classic (expensive) way6

As we’ve already predicted, more than 100 research groups are trying to develop a corona-vaccine, but only few will get final approval, and it’s more or less defined which ones.

Countries like China and Russia which are less dependent from the WHO than most western countries, will get their own vaccine but it’s doubtful if they will get approval for the US and European market.

References:

The History of the mRNA Vaccines – The History of Vaccines

mRNA Vaccines Might Prove Catastrophic in a Rushed Coronavirus Response – NewsWars 

BioNTech Says Can Make Mutation-Beating Vaccine In 6 Weeks (ndtv.com)

https://www.ema.europa.eu/en/human-regulatory/marketing-authorisation/conditional-marketing-authorisation

https://snacksafely.com/2020/12/what-we-know-about-peg-suspected-as-the-cause-of-reactions-to-pfizers-covid-19-vaccine/

How the top 3 COVID-19 vaccines compare, in one chart (businessinsider.com)

Behind the name of the vaccine it says:

Conditional marketing authorization granted.’

It is important to know what that means.

Therefore, below is the explanation of this term from the website of the European Medicine Agency (EMA).

 

 

During the COVID-19 pandemic, EMA’s conditional marketing authorization is being used to accelerate the approval in the EU of safe and effective COVID-19 treatments and vaccines.

This is in line with EU regulations that provide conditional marketing authorization for rapid authorization during public health emergencies to speed up approval and save lives.

This allows for marketing authorization as soon as sufficient data is available showing that the benefits of the drug outweigh the risks, with strict safeguards and ongoing post-authorization controls.

During public health emergencies, it can also be combined with data tracking during the development of a promising drug to further accelerate evaluation.

Conditional marketing authorization is the most appropriate tool to make COVID-19 vaccines available to all EU citizens and enable massive vaccination campaigns.